Lock your doors (and Windows): Stepping out for a minute? Remember to press Windows-L to lock your computer's screen so that no one can nose around without entering your account password.
Run, Windows, run: To access the Run command easily, press Windows-R.
Keyboard explorer: Want to open a new Windows Explorer window without leaving the keyboard? Press Windows-E.
Declutter your desktop: Access your desktop instantly by pressing Windows-D to hide all open windows. Press Windows-D again to return to where you were.