Any changes aren't likely to have any impact on technology at Wanko's company anytime soon, he said. "Big pharma moves very slow. We'll see virtual machines in production in two years, but not now. We certainly won't see Vista until Bill Gates hangs up his keyboard. We might see SQL Server 2005 in some applications, but pharma is largely an Oracle vertical."

Ann M. Harten, vice president of global information systems for Holland, Mich.-based office furniture and architectural interior supplier Haworth Inc., said, "Bill has had a terrific run with wonderful innovation. A new perspective -- with Bill's ongoing guidance -- might be a refreshing approach." The move is "probably a good thing [for Microsoft], particularly if the focus and execution shifts to accurate and usable delivery."

Brian Young, vice president for IT at Omaha-based Creighton University, lauded Gates' plans. "I think it is good that Bill will focus his efforts with his foundation, helping address global issues that face our human existence," Young said. "His time spent with the foundation will be rewarding to many."

Young said that even after leaving Microsoft, "Bill will remain connected in many ways."

Adrian Brown, CIO at Greenville, S.C.-based Canal Insurance Co., said, "An era is ending. I am grateful that Gates stayed as long as he did. He could have cashed out years ago. What an impact one man has made."