Long-term exposure to some BFRs (certain PBDEs) has been associated with abnormal brain development in animals, with possible long-term impacts on memory, learning and behavior.

Some BFRs also interfere with thyroid and estrogen hormone systems. TBBPA has been shown in some laboratory studies to be toxic to the nervous system. The presence of PBDE and TBBPA, or other bromine containing chemicals, in electronics products has the potential to generate brominated dioxins and furans, when the electronic waste comes to be smelted, incinerated or burnt in the open.