I feel your pain. Sometimes I feel like I spend half my morning just sifting through all this stuff.
If your email provider is AOL, Gmail, Google Apps, Mac.com, Me.com, or Yahoo, check out . This potentially awesome service aggregates any or all of your subscribed newsletters into a single daily digest, effectively turning a boatload of inbox clutter into just one email.
All you do is sign into your account, then wait while Swizzle searches your inbox for newsletters.
When it's done, you'll see a list of everything that qualifies. (Swizzle found over in my inbox. Sheesh!) For each sender, you have the option of clicking (which instantly takes you to the unsubscribe page for that company or service) or .
The latter option intercepts subsequent emails from that source and adds them to your Swizzle digest, which can be delivered daily (morning, noon, or evening time) or on any given day of the week. (It would be nice if you could divert some newsletters into a weekly digest and others into a daily one.)