When you first open GenoPro, you're hit with a paragraph of text designed to help you: a number of shortcuts and tips. However good your memory is, it's unlikely you are going to remember all of this--and you will need it--but it's okay. If you forget, simply go to File > New and it will reappear.
GenoPro also opens with five different toolbars. It's a little daunting, but you can hide them all by visiting the View menu.
Once you have GenoPro's UI under control, you can either import a GEDCOM file (GEDCOM is the standard Genealogical Data Communication format used by most genealogical software to share information) or start entering family information into the database.
The Family Wizard (obtained by hitting the f key on your keyboard, or via the Tools menu) asks you for basic data--first, middle, and last names; date of birth; date of death--of father, mother, and children. This is generally the same process with any genealogy software program; you're populating the database.
GenoPro's method is uncomplicated right off the bat, but there are a few items that are not clear. For example, there are many fields in the Children area that you can't access from the family wizard--and you may end up searching the help file.