The affect Windows, Macintosh, Linux, Google Chrome and users of Android 2.x, 3.x and 4.x devices, Adobe said in its advisory.
The patches address four memory corruption vulnerabilities -- CVE-2012-4163, CVE-2012-4164, CVE-2012-4165 and CVE-2012-4166 -- and an integer overflow vulnerability, CVE-2012-4167. Also fixed is a cross-domain information leak vulnerability, CVE-2012-4168.
"These updates address vulnerabilities that could cause a crash and potentially allow an attacker to take control of the affected system," Adobe said.
Windows and Apple users should use Flash version 11.4.402.265, and the up-to-date Linux version is 11.2.202.238. For Adobe's AIR runtime, which allows Web applications to perform functions outside of a Web browser, Windows and Apple users should move to version 3.4.0.2540.
Last week, Adobe pushed out a fix for Flash for , which the company said had been used in limited attacks. The problem can cause Flash to crash, or, at worst, allow an attacker to take over control of the computer.